Niam Yaraghi

Modern Experimental Designs for Business Research Part 1: Foundations of Experimental Research

Foundations: From Secondary Data to Experiments

Overview of Secondary Data Analysis and Key Challenges

Secondary data analysis leverages existing data sources to infer causal relationships. While it offers scalability and cost efficiency, it is particularly susceptible to biases and relies on strong assumptions for causal inference.

Key Susceptibilities to Bias

1. Omitted Variable Bias

  • Definition: Occurs when a confounding variable is not accounted for, leading to misleading estimates of the treatment effect.

  • Example: Estimating the effect of an advertising campaign on sales without considering seasonal trends.

2. Selection Bias

  • Definition: Arises when the treatment group is not representative of the population due to non-random assignment.

  • Example: Comparing outcomes for self-selected participants in a program versus non-participants.

3. Measurement Bias

  • Definition: Errors in how variables are recorded or defined, affecting validity.

  • Example: Using inaccurate proxies for customer satisfaction in survey data.

Required Assumptions for Causal Inference

Secondary data analysis often requires strong assumptions to mitigate these biases and enable credible causal interpretations.

1. Parallel Trends Assumption (Difference-in-Differences)

  • What it Ensures: Ensures that, in the absence of treatment, treated and control groups would follow the same trend over time.

  • Relationship with Bias: Helps control for omitted variables that affect both groups equally over time.

2. No Confounding Variables (Interrupted Time Series)

  • What it Ensures: Assumes no unmeasured factors simultaneously influence the observed trends and the intervention’s timing.

  • Relationship with Bias: Minimizes omitted variable bias by isolating the intervention’s effect.

3. Exogeneity (Instrumental Variables)

  • What it Ensures: Requires that the instrument (variable inducing treatment assignment) affects the outcome only through the treatment.

  • Relationship with Bias: Addresses selection bias by mimicking randomization through an exogenous instrument.

Advantages and Strengths of Experiments

Experiments offer unique advantages that make them a powerful tool for causal inference in research. These strengths include:

1. Random Assignment

  • Elimination of Selection Bias: Random assignment ensures that treatment and control groups are statistically equivalent, eliminating systematic differences between the groups. This allows researchers to attribute observed differences in outcomes directly to the treatment.

  • Foundation for Causal Inference: By creating comparable groups, random assignment minimizes confounding variables and ensures the validity of causal claims.

2. Controlled Environments

  • Manipulation of Variables: Experiments enable researchers to directly manipulate independent variables and observe their impact on outcomes, offering unparalleled flexibility in testing hypotheses.

  • Flexibility in Testing Theories: Researchers are not constrained by existing datasets, allowing them to explore a wider range of questions and theories that observational data cannot accommodate.

3. Direct Causal Inference

  • Bias-Free Measurement: Experiments measure the treatment effect directly without the biases commonly found in secondary data analysis.

  • Simplified Analysis: The absence of biases and the straightforward structure of treatment and control groups often simplify statistical analysis, making results more robust and interpretable.

Poor Econometrician’s Time Machine

The most definitive method to examine the causal effects of a treatment is to use a time machine! Ideally, researchers would treat participants, observe the outcomes, then travel back in time to retrieve the same individuals, this time withholding treatment, and observe the outcomes again. This approach allows the researcher to compare the results from both scenarios. The difference between these outcomes would then represent the pure causal impact of the treatment: E[yi∣Di=1]−E[yi∣Di=0].E\left[y_i \mid D_i = 1\right] - E\left[y_i \mid D_i = 0\right].

We can write the observed outcome as follows: yi={y1iif Di=1,y0iif Di=0.y_i = \begin{cases} y_{1i} & \text{if } D_i = 1, \\ y_{0i} & \text{if } D_i = 0. \end{cases}

This allows us to rewrite the outcome as: yi=y0i+(y1i−y0i)Di.y_i = y_{0i} + \left(y_{1i} - y_{0i}\right) D_i.

Therefore: E[yi∣Di=1]=E[y1i∣Di=1],E\left[y_i \mid D_i = 1\right] = E\left[y_{1i} \mid D_i = 1\right], E[yi∣Di=0]=E[y0i∣Di=0].E\left[y_i \mid D_i = 0\right] = E\left[y_{0i} \mid D_i = 0\right].

Using this notation, we can rewrite the initial formula as: E[yi∣Di=1]−E[yi∣Di=0]=E[y1i∣Di=1]−E[y0i∣Di=0].E\left[y_i \mid D_i = 1\right] - E\left[y_i \mid D_i = 0\right] = E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 0\right].

By subtracting and then adding the term E[y0i∣Di=1]E\left[y_{0i} \mid D_i = 1\right], we have: {E[y1i∣Di=1]−E[y0i∣Di=1]}+{E[y0i∣Di=1]−E[y0i∣Di=0]}.\left\{E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 1\right]\right\} + \left\{E\left[y_{0i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 0\right]\right\}.

The first term, E[y1i∣Di=1]−E[y0i∣Di=1]E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 1\right], is the average causal treatment effect on the treated (ATT). This shows the difference between the treated outcome and the counterfactual outcome for the untreated for the same individuals. This assumes that the researcher, equipped with a hypothetical time machine, could travel back in time, retrieve the same individuals, withhold treatment, and observe what would have happened to these experiment participants had they not been treated.

The second term introduces significant complications. It involves the researcher using the time machine to go back and find the individuals who were originally treated, withhold treatment this time, and observe the outcomes. These results are then compared to the actual outcomes of those who were never treated in the first place. If the researcher had any biases in selecting whom to enroll in his experiments, that would show here. If the researcher had any biases in selecting whom to enroll in the experiments, that would show here. That is, the counterfactual outcomes for the treated would be different from the actual outcomes of the untreated individuals. There should ideally be no differences between treated and untreated individuals unrelated to the treatment.

If there were no selection bias, the following equation would hold: E[y1i∣Di=1]−E[y0i∣Di=0]=E[y1i∣Di=1]−E[y0i∣Di=1].E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 0\right] = E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 1\right].

That is, the average difference in the outcome would be the average treatment effect on the treated (ATT). This simplifies further as: E[y1i∣Di=1]−E[y0i∣Di=0]=E[y1i∣Di=1]−E[y0i∣Di=1]E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 0\right] = E\left[y_{1i} \mid D_i = 1\right] - E\left[y_{0i} \mid D_i = 1\right] =E[y1i−y0i∣Di=1]=E[y1i−y0i].= E\left[y_{1i} - y_{0i} \mid D_i = 1\right] = E\left[y_{1i} - y_{0i}\right].

The point is, random assignment of treatment acts as the poor econometrician’s time machine!

Reliability and Validity in Empirical Research

Reliability and validity are fundamental concepts in econometrics and experimental design, ensuring the robustness of research findings.

  • Reliability refers to the consistency and stability of measurements. Reliable methods produce the same results under the same conditions. For example:

    • A scale is reliable if it shows the same weight every morning when conditions are unchanged. In business research, reliability ensures that repeating a survey with the same population yields consistent outcomes.

  • Validity assesses whether a method measures what it is intended to measure. Validity ensures the accuracy of the causal relationships inferred. For example:

    • A scale is valid if it measures weight rather than an unrelated attribute like height. In a study on advertising’s impact on sales, validity requires isolating the causal effect of advertising without interference from factors like seasonality or competitor actions.

Together, reliability and validity ensure that experiments yield meaningful, reproducible results, forming the backbone of empirical research.

Key Principles of Experimental Design

Experimental design refers to a structured and systematic approach to identifying causal relationships. The goal is to isolate the effect of a treatment or intervention on an outcome of interest, controlling for confounding factors and ensuring that observed effects are attributable solely to the treatment.

  • Randomization: Ensuring Validity
    Randomization addresses selection bias and omitted variable bias by evenly distributing both observed and unobserved factors across treatment and control groups. This ensures internal validity by isolating the causal effect of the treatment. Without randomization, differences in outcomes might reflect pre-existing disparities rather than the treatment effect.

  • Replication: Ensuring Reliability
    Replication checks for consistency and reliability by repeating experiments with new samples or under different conditions. Reliable findings demonstrate stability and reproducibility, forming the foundation of empirical research.

  • Control: Supporting Validity
    Control minimizes measurement bias and allows researchers to directly manipulate variables of interest while holding others constant. This precise manipulation ensures that the observed changes in outcomes can be attributed solely to the treatment, supporting the validity of the findings.

Scalability in Experiments

Scalability refers to the ability to expand an experimental design to larger populations, different contexts, or real-world settings without compromising the validity, reliability, or interpretability of results. While experiments, particularly randomized controlled trials (RCTs), are a gold standard for causal inference, scaling them up introduces unique challenges.

Key Challenges in Scalability

Representativeness:

  • Definition: Experimental samples often do not reflect the broader population due to limited resources or constraints in participant recruitment.

  • Problem: Findings from unrepresentative samples may lack external validity, making it difficult to generalize results to other populations or settings.

  • Example: A study on an educational intervention conducted only in urban schools may not apply to rural areas.

Voltage Effects:

  • Definition: Voltage effects occur when the effectiveness of an intervention diminishes as it scales from a controlled experimental setting to real-world applications.

  • Problem: Factors such as reduced adherence, variations in implementation fidelity, or unforeseen external influences in real-world settings can undermine effectiveness.

  • Example: A personalized marketing campaign showing strong results in a small pilot may falter when scaled due to less precise targeting or broader audience variability.

Heterogeneous Treatment Effects:

  • Definition: The impact of an intervention may vary across different subgroups or settings.

  • Problem: Experiments often identify average treatment effects, which may obscure important differences in how various populations respond.

  • Example: A job training program may benefit younger participants more than older ones, but this nuance might not be evident without subgroup analyses.

Required readings

Al-Ubaydli, O., Lee, M. S., List, J. A., Mackevicius, C. L., and Suskind, D. (2021). How Can Experiments Play a Greater Role in Public Policy? Twelve Proposals from an Economic Model of Scaling. Behavioural Public Policy, 5(1), 2–49. https://doi.org/10.1017/bpp.2020.17

Feng, Y. K., Claggett, J. L., Karahanna, E., and Tam, K. Y. (2022). A Randomized Field Experiment to Explore the Impact of Herding Cues as Catalysts for Adoption. MIS Quarterly, 46(2), 1135–1164. https://doi.org/10.25300/MISQ/2022/16141

Cecchi, F., Lensink, R., and Slingerland, E. (2024). Ambiguity Attitudes and Demand for Weather Index Insurance With and Without a Credit Bundle: Experimental Evidence from Kenya. Journal of Behavioral and Experimental Finance, 41, 100885. https://doi.org/10.1016/j.jbef.2023.100885

Lazar, M., Miron-Spektor, E., Chen, G., Goldfarb, B., Erez, M., and Agarwal, R. (2022). Forming Entrepreneurial Teams: Mixing Business and Friendship to Create Transactive Memory Systems for Enhanced Success. Academy of Management Journal, 65(4), 1110–1138. https://doi.org/10.5465/amj.2020.0393

Rafieian, O., Kapoor, A., and Sharma, A. (2025). Multiobjective Personalization of Marketing Interventions. Marketing Science, 44(2), 457–477. https://doi.org/10.1287/mksc.2023.0122

Yaraghi, N. (2015). An Empirical Analysis of the Financial Benefits of Health Information Exchange in Emergency Departments. Journal of the American Medical Informatics Association, 22(6), 1169–1172. https://doi.org/10.1093/jamia/ocv068

Yaraghi, N. (2026). Modern Experimental Designs for Business Research: Course Notes for BTE 693. Version 1.0. University of Miami. https://niamyaraghi.com/experimental-designs Version 1.0, September 2026. PDF.